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Current Aspects of the Endocannabinoid System and Targeted THC and CBD Phytocannabinoids as Potential Therapeutics for Parkinson’s and Alzheimer’s Diseases: a Review

OPEN ACESS - Molecular Neurobiology (2020) 57:4878–4890 - Revisão - 2020

GERADO POR INTELIGÊNCIA ARTIFICIAL A neurodegeneração que leva à doença de Parkinson (DP) e à doença de Alzheimer (DA) tornou-se um grande fardo para a ... (Ver mais)

Cannabis, cannabinoids, and health

OPEN ACCESS - Dialogues in Clinical Neuroscience - Revisão - 2017

Cannabis (also known as marijuana) is the most frequently used illicit psychoactive substance in the world. Though it was long considered to be a "soft" ... (Ver mais)

The Cannabis Terpenes

OPEN ACCESS - Molecules - Revisão - 2020

Terpenes are the primary constituents of essential oils and are responsible for the aroma characteristics of cannabis. Together with the cannabinoids, te ... (Ver mais)

Cannabis Addiction and the Brain: a Review

OPEN ACCESS - Journal of Neuroimmune Pharmacology - Revisão - 2018

Cannabis is the most commonly used substance of abuse in the United States after alcohol and tobacco. With a recent increase in the rates of cannabis use ... (Ver mais)

Cannabis Use, Lung Cancer, and Related Issues

OPEN ACCESS - Journal of Thoracic Oncology - Revisão - 2018

The cannabis plant and its derivatives have been exploited for centuries for recreational and medicinal purposes, with millions of regular users around t ... (Ver mais)

Cannabis use and cannabis use disorder

OPEN ACCESS - Nature Reviews Disease Primers - Revisão - 2021

Cannabis use disorder (CUD) is an underappreciated risk of using cannabis that affects ~10% of the 193 million cannabis users worldwide. The individual a ... (Ver mais)

Cannabis, from plant to pill

OPEN ACCESS - British Journal of Clinical Pharmacology - Revisão - 2018

The therapeutic application of cannabis is attracting substantial public and clinical interest. The cannabis plant has been described as a veritable ‘tre ... (Ver mais)

Meta-analysis of the Association Between the Level of Cannabis Use and Risk of Psychosis

OPEN ACCESS - Schizophrenia Bulletin - Meta análise - 2016

Cannabis use has been reported to induce long-lasting psychotic disorders and a dose-response relationship has been observed. We performed a systematic r ... (Ver mais)

Terpenes in Cannabis sativa – From plant genome to humans

OPEN ACCESS - Plant Science - Revisão - 2019

Cannabis sativa (cannabis) produces a resin that is valued for its psychoactive and medicinal properties. Despite being the foundation of a multi-billion ... (Ver mais)

Therapeutic potential of Cannabis sativa

OPEN ACCESS - Revista Médica de Chile - Revisão - 2017

Cannabis sativa (marihuana) is considered an illicit drug due to its psychoactive properties. Recently, the Chilean government opened to the use cannabis ... (Ver mais)

Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

OPEN ACCESS - British Journal of Pharmacology - Revisão - 2011

Tetrahydrocannabinol (THC) has been the primary focus of cannabis research since 1964, when Raphael Mechoulam isolated and synthesized it. More recentl ... (Ver mais)

The short-term impact of 3 smoked cannabis preparations versus placebo on PTSD symptoms: A randomized cross-over clinical trial

OPEN ACCESS - PLOS ONE - Teste controlado randomizado - 2021

Importance There is a pressing need for development of novel pharmacology for the treatment of Posttraumatic Stress Disorder (PTSD). Given increasing u ... (Ver mais)

Safety of Medical Cannabis in Neuropathic Chronic Pain Management

OPEN ACCESS - Molecules - Revisão - 2021

Products derived from the plant Cannabis sativa are widely appreciated for their analgesic properties and are employed for the treatment of chronic neu ... (Ver mais)

Changing landscape of cannabis: novel products, formulations, and methods of administration

OPEN ACCESS - Current Opinion in Psychology - Revisão - 2019

Laws regulating cannabis have changed radically in the U.S. and abroad. Historically, users smoked dried cannabis flowers that contained Δ9-tetrahydroc ... (Ver mais)

Cannabis and pain: a scoping review

OPEN ACCESS - Brazilian Journal of Anesthesiology - Revisão - 2022

For centuries, cannabis has been used with many different purposes, including medicinal use, usually bypassing any formal approval process. However, du ... (Ver mais)

Applications of Cannabis Sativa L. in Food and Its Therapeutic Potential: From a Prohibited Drug to a Nutritional Supplement

OPEN ACCESS - Molecules - Revisão - 2021

Hemp (Cannabis sativa L.) is a herbaceous anemophilous plant that belongs to the Cannabinaceae family. The cannabis seed (hemp) has long been utilized ... (Ver mais)

Cannabis/Cannabinoids for Treating COVID-19 Associated Neuropsychiatric Complications

OPEN ACCESS - Journal of Neuroimmune Pharmacology - Informe - 2021

COVID-19 epidemic has resulted in devastating mortality and morbidity consisting of socioeconomic and health efects that have included respiratory/pulm ... (Ver mais)

General and oral health implications of cannabis use

OPEN ACCESS - Australian Dental Journal - Revisão - 2005

Cannabis, commonly known as marijuana, is themost frequently used illicit drug in Australia.Therefore, oral health care providers are likely toencounte ... (Ver mais)

Low-dose vaporized cannabis significantly improves neuropathic pain

OPEN ACCESS - Journal of Pain - Teste controlado randomizado - 2013

We conducted a double-blind, placebo-controlled, crossover study evaluating the analgesic efficacy of vaporized cannabis in subjects, the majority of w ... (Ver mais)

The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease

OPEN ACCESS - International Journal of Molecular Sciences - Revisão - 2020

Cannabidiol (CBD) is a non-intoxicating and generally well-tolerated constituent of cannabis which exhibits potential beneficial properties in a wide r ... (Ver mais)

Recent advances in Cannabis sativa genomics research

OPEN ACCESS - New Phytologist - Revisão - 2021

Cannabis (Cannabis sativa L.) is one of the oldest cultivated plants purported to have unique medicinal properties. However, scientific research of can ... (Ver mais)

It Is Our Turn to Get Cannabis High: Put Cannabinoids in Food and Health Baskets

OPEN ACCESS - Molecules - Revisão - 2020

Cannabis is an annual plant with a long history of use as food, feed, fiber, oil, medicine, and narcotics. Despite realizing its true value, it has not ... (Ver mais)

The Current State of Pharmacological Treatments for Cannabis Use Disorder and Withdrawal

OPEN ACCESS - Neuropsychopharmacology - Revisão - 2018

Cannabis use disorder (CUD) commonly occurs and carries a notable economic and functional burden at both individual and societal levels. While there ar ... (Ver mais)

Cannabis, the Endocannabinoid System and Immunity-the Journey from the Bedside to the Bench and Back

OPEN ACCESS - International Journal of Molecular Sciences - Revisão - 2020

The Cannabis plant contains numerous components, including cannabinoids and other active molecules. The phyto-cannabinoid activity is mediated by the e ... (Ver mais)

Medical cannabis education among healthcare trainees: A scoping review

OPEN ACCESS - Complementary Therapies in Medicine - Revisão - 2021

Objectives: It has been previously demonstrated that healthcare professionals would like additional education on medical cannabis. However, there has n ... (Ver mais)

Cannabis related side effects in otolaryngology: a scoping review

OPEN ACCESS - Journal of Otolaryngology - Head & Neck Surgery - Revisão - 2021

Background: Cannabis has been rapidly legalized in North America; however, limited evidence exists around its side effects. Health Canada defines side ... (Ver mais)

Different Effects of Cannabis Abuse on Adolescent and Adult Brain

OPEN ACCESS - Pharmacology - Revisão - 2020

Cannabis abuse is a common phenomenon among adolescents. The dominant psychoactive substance in Cannabis sativa is tetrahydrocannabinol (THC). However, ... (Ver mais)

Adverse Effects of Recreational and Medical Cannabis

OPEN ACCESS - Psychopharmacology Bulletin - Revisão - 2021

Purpose of review: This comprehensive review discusses the adverse effects known today about marijuana, for either medical or recreational use. It revi ... (Ver mais)

Traditional uses of Cannabis: An analysis of the CANNUSE database

OPEN ACCESS - Journal of Ethnopharmacology - Revisão - 2021

Ethnopharmacological relevance: Cannabis is one of the most versatile genera in terms of plant use and has been exploited by humans for millennia. Nowa ... (Ver mais)

Inflammatory Bowel Disease and Cannabis: A Practical Approach for Clinicians

OPEN ACCESS - Advances in Therapy - Abordagem Prática - 2021

Although still not approved at the federal level for medical or adult recreational use, cannabis has been approved in the United States (USA) by indivi ... (Ver mais)

Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community

OPEN ACCESS - Scientific Reports - Artigo Original - 2018

Recent surveys suggest that many parents are using illicit cannabis extracts in the hope of managing seizures in their children with epilepsy. In the c ... (Ver mais)

Evaluation of Patient Reported Safety and Efficacy of Cannabis From a Survey of Medical Cannabis Patients in Canada

OPEN ACCESS - Frontiers in Public Health - Artigo Original - 2021

With the medical use of cannabis permitted in Canada since 2001, patients seek to use this botanical drug to treat a range of medical conditions. Howev ... (Ver mais)

Cannabinoids and Epilepsy

OPEN ACCESS - Neurotherapeutics - Revisão - 2015

Cannabis has been used for centuries to treat seizures. Recent anecdotal reports, accumulating animal model data, and mechanistic insights have raised ... (Ver mais)

Children as voices and images for medicinal cannabis law reform

OPEN ACCESS - Monash Bioethics Review - Artigo Original - 2021

This article situates the movement for the legalisation of medicinal cannabis within the bigger picture of the impetus toward recreational cannabis leg ... (Ver mais)

Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment

OPEN ACCESS - International Journal of Molecular Sciences - Revisão - 2021

Cannabis sativa L. turned out to be a valuable source of chemical compounds of various structures, showing pharmacological activity. The most important ... (Ver mais)

Species‐specific susceptibility to cannabis‐induced convulsions

OPEN ACCESS - British Journal of Pharmacology - Artigo Original - 2019

Numerous claims are made for cannabis therapeutic utility upon human seizures, but concerns persist about risks. A potential confounder is the presence ... (Ver mais)

Cannabis effects on brain structure, function, and cognition: considerations for medical uses of cannabis and its derivatives

OPEN ACCESS - The American Journal of Drug and Alcohol Abuse - Revisão - 2020

Cannabis is the most widely used illicit substance worldwide, and legalization for recreational and medical purposes has substantially increased its av ... (Ver mais)

Family attitudes about and experiences with medical cannabis in children with cancer or epilepsy: an exploratory qualitative study

OPEN ACCESS - CMAJ Open - Artigo Original - 2021

Cannabis is legal for recreational and medical use in Canada. Our aim was to explore family experiences using medical cannabis for children with severe ... (Ver mais)

Efficacy of Phytocannabinoids in Epilepsy Treatment: Novel Approaches and Recent Advances

OPEN ACCESS - International Journal of Environmental Research and Public Health - Revisão - 2021

Epilepsy is a neurological disorder mainly characterised by recurrent seizures that affect the entire population diagnosed with the condition. Currentl ... (Ver mais)

Daily Cannabis Use is Associated with Lower CNS Inflammation in People with HIV

OPEN ACCESS - Journal of the International Neuropsychological Society - Artigo Original - 2021

ecent cannabis exposure has been associated with lower rates of neurocognitive impairment in people with HIV (PWH). Cannabis’ anti-inflammatory propert ... (Ver mais)

Full-Spectrum Cannabis Extract Microdepots Support Controlled Release of Multiple Phytocannabinoids for Extended Therapeutic Effect

OPEN ACCESS - ACS Applied Materials & Interfaces - Artigo Original - 2020

The therapeutic effect of the Cannabis plant largely depends on the presence and specific ratio of a spectrum of phytocannabinoids. Although prescripti ... (Ver mais)

Therapeutic use of cannabis and cannabinoids: an evidence mapping and appraisal of systematic reviews

OPEN ACCESS - BMC Complementary Medicine and Therapies - Revisão - 2020

Although cannabis and cannabinoids are widely used with therapeutic purposes, their claimed efficacy is highly controversial. For this reason, medical ... (Ver mais)

Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials

OPEN ACCESS - Molecules - Revisão - 2019

Cannabidiol (CBD) is one of the cannabinoids with non-psychotropic action, extracted from Cannabis sativa. CBD is a terpenophenol and it has received a ... (Ver mais)

Cannabis Contaminants Limit Pharmacological Use of Cannabidiol

OPEN ACCESS - Frontiers in Pharmacology - Artigo Original - 2020

For nearly a century, Cannabis has been stigmatized and criminalized across the globe, but in recent years, there has been a growing interest in Cannab ... (Ver mais)

Cannabis Exposure is Associated with a Lower Likelihood of Neurocognitive Impairment in People Living with HIV

OPEN ACCESS - JAIDS Journal of Acquired Immune Deficiency Syndromes - Artigo Original - 2021

Aging and HIV have adverse effects on the CNS, including increased inflammation and neural injury, and confer risk for neurocognitive impairment (NCI). ... (Ver mais)

Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders

OPEN ACCESS - Epilepsia. - Revisão - 2016

To present a summary of current scientific evidence about the cannabinoid, cannabidiol (CBD) with regards to their relevance to epilepsy and other sele ... (Ver mais)

Bioactive Chemical Composition of Cannabis Extracts and Cannabinoid Receptors

OPEN ACCESS - Molecules - Revisão - 2020

Cannabis is widely used as a therapeutic drug, especially by patients suffering from psychiatric and neurodegenerative diseases. However, the complex i ... (Ver mais)

Cannabis and Athletic Performance

OPEN ACCESS - Sports Med - Revisão - 2021

Cannabis is widely used for both recreational and medicinal purposes on a global scale. There is accumulating interest in the use of cannabis and its c ... (Ver mais)

Cannabis for pediatric epilepsy: protocol for a living systematic review

OPEN ACCESS - Systematic Reviews - Revisão - 2018

Pediatric epilepsy, including treatment-resistant forms, has a major effect on the quality of life, morbidity, and mortality of affected children. Inte ... (Ver mais)

Human Laboratory Models of Cannabis Use: Applications for Clinical and Translational Psychiatry Research

OPEN ACCESS - Frontiers in Psychiatry - Revisão - 2021

Cannabis is increasingly used by individuals with mental health diagnoses and often purported to treat anxiety and various other psychiatric symptoms. ... (Ver mais)

Cannabinoids and Terpenes: How Production of Photo-Protectants Can Be Manipulated to Enhance Cannabis sativa L. Phytochemistry

OPEN ACCESS - Frontiers in Plant Science - Artigo Original - 2021

Cannabis sativa L. is cultivated for its secondary metabolites, of which the cannabinoids have documented health benefits and growing pharmaceutical po ... (Ver mais)

The Use of Cannabis for Headache Disorders

OPEN ACCESS - Cannabis and Cannabinoid Research Journal - Revisão - 2017

Headache disorders are common, debilitating, and, in many cases, inadequately managed by existing treatments. Although clinical trials of cannabis for ... (Ver mais)

Medical Cannabis for Older Patients—Treatment Protocol and Initial Results

OPEN ACCESS - Journal of Clinical Medicine - Revisão - 2019

Older adults may benefit from cannabis treatment for various symptoms such as chronic pain, sleep difficulties, and others, that are not adequately con ... (Ver mais)

Acute and Severe Acute Pancreatitis and the Effect of Cannabis in States Before and After Legalization Compared to States Without Legalized Cannabis

OPEN ACCESS - Pancreas. - Revisão - 2022

Cannabis legalization has increased its use. The incidence of acute pancreatitis (AP) and severe acute pancreatitis (SAP) has also increased. In this s ... (Ver mais)

Medical Cannabis in Pediatric Oncology: Friend or Foe?

OPEN ACCESS - Pharmaceuticals (Basel) - Revisão - 2022

The antineoplastic effects of cannabis have been known since 1975. Since the identification of the components of the endogenous cannabinoid system (ECS ... (Ver mais)

Cannabis against chronic musculoskeletal pain: a scoping review on users and their perceptions

OPEN ACCESS - Journal of Cannabis Research - Revisão - 2021

Chronic musculoskeletal pain (CMP) may lead to reduced physical function and is the most common cause of chronic non-cancer pain. Currently, the pharma ... (Ver mais)

Is cannabidiol a drug acting on unconventional targets to control drug‐resistant epilepsy?

OPEN ACCESS - Epilepsia Open - Revisão - 2020

Cannabis has been considered as a therapeutic strategy to control intractable epilepsy. Several cannabis components, especially cannabidiol (CBD), indu ... (Ver mais)

The antimicrobial effect behind Cannabis sativa

OPEN ACCESS - Pharmacology Research & Perspectives - Artigo Original - 2021

The development of multidrug‐resistant bacteria has revealed the need for new antimicrobial compounds. Cannabis sativa preparations have a long history ... (Ver mais)

A narrative review of the ethnomedicinal usage of Cannabis sativa Linnaeus as traditional phytomedicine by folk medicine practitioners of Bangladesh

OPEN ACCESS - Journal of Cannabis Research - Revisão - 2021

There is a worldwide interest in the use of Cannabis sativa for biomedicine purposes. Cannabis has ethnomedicinal usage as a natural medicine in Bangla ... (Ver mais)


OPEN ACCESS - Pharmacology Biochemistry and Behavior - Revisão - 2021

The phytocannabinoid Δ9-tetrahydrocannabinol (THC) was isolated and synthesized in the 1960s. Since then, two synthetic cannabinoids (SCBs) targeting t ... (Ver mais)

Cannabis and the Developing Adolescent Brain

OPEN ACCESS - Current Treatment Options in Psychiatry - Revisão - 2020

This review summarizes (1) recent trends in delta-9-tetrahydrocannabionol [THC] and cannabidiol (CBD) content in cannabis products, (2) neurobiological ... (Ver mais)

Cannabidiol Treatment for Refractory Epilepsies in Pediatrics

OPEN ACCESS - Frontiers in Pharmacology - Revisão - 2020

Cannabis extracts in oil are becoming increasingly available, and, during the last years, there has been growing public and scientific interest about t ... (Ver mais)

Cannabis and cannabidiol use among autistic and non-autistic adults in the UK: a propensity score-matched analysis

OPEN ACCESS - BMJ Open - Revisão - 2021

To assess whether autistic and non-autistic adults differ in their cannabis and cannabidiol (CBD) use, their perceptions of cannabinoid products and th ... (Ver mais)

Secondary Metabolites Profiled in Cannabis Inflorescences, Leaves, Stem Barks, and Roots for Medicinal Purposes

OPEN ACCESS - Scientific Reports - Revisão - 2020

Cannabis research has historically focused on the most prevalent cannabinoids. However, extracts with a broad spectrum of secondary metabolites may hav ... (Ver mais)

Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy

OPEN ACCESS - Epilepsy & Behavior - Relato de Caso - 2014

Severe childhood epilepsies are characterized by frequent seizures, neurodevelopmental delays and impaired quality of life. In these treatment-resistan ... (Ver mais)

Pain in the neurodegenerating brain: insights into pharmacotherapy for Alzheimer disease and Parkinson disease

OPEN ACCESS - Pain. - Revisão - 2021

Cannabis, a Miracle Drug with Polyvalent Therapeutic Utility: Preclinical and Clinical-Based Evidence

OPEN ACCESS - Medical Cannabis and Cannabinoids - Revisão - 2021

Cannabis sativa L. is an annual herbaceous dioecious plant which was first cultivated by agricultural human societies in Asia. Over the period of time, ... (Ver mais)

Interaction of Cannabis Use and Aging: From Molecule to Mind

OPEN ACCESS - Journal of Dual Diagnosis - Revisão - 2021

Given the aging Baby Boomer generation, changes in cannabis legislation, and the growing acknowledgment of cannabis for its therapeutic potential, it i ... (Ver mais)

Cannabinoid Formulations and Delivery Systems: Current and Future Options to Treat Pain

OPEN ACCESS - Drugs - Revisão - 2021

The field of Cannabis sativa L. research for medical purposes has been rapidly advancing in recent decades and a growing body of evidence suggests that ... (Ver mais)

Metabolomic Fingerprint of Behavioral Changes in Response to Full-Spectrum Cannabis Extracts

OPEN ACCESS - Frontiers in Pharmacology - Revisão - 2022

Numerous existing full-spectrum cannabis extract products have been used in clinical trials for the treatment of various diseases. Despite their effica ... (Ver mais)

From Cannabis sativa to Cannabidiol: Promising Therapeutic Candidate for the Treatment of Neurodegenerative Diseases

OPEN ACCESS - Frontiers in Pharmacology - Revisão - 2020

Cannabis sativa, commonly known as marijuana, contains a pool of secondary plant metabolites with therapeutic effects. Besides Δ9-tetrahydrocannabinol ... (Ver mais)

Relationship Between Cannabis Use and Erectile Dysfunction: A Systematic Review and Meta-Analysis

OPEN ACCESS - American Journal of Men' s Health - Revisão - 2019

Globally, there is increasing usage and legalization of cannabis.In addition to its reported therapeutic effects, cannabis ... (Ver mais)

Potential and Limits of Cannabinoids in Alzheimer ’ s Disease Therapy

OPEN ACCESS - Biology (Basel). - Revisão - 2021

Alzheimer ’ s disease (AD) is a detrimental brain disorder characterized by a gradual cognitive decline and neuronal deterioration.To date, the trea ... (Ver mais)

Can We Treat Neuroinflammation in Alzheimer ’ s Disease ?

OPEN ACCESS - International Journal of Molecular Sciences - Revisão - 2020

Alzheimer ’ s disease (AD), considered the most common type of dementia, is characterized by a progressive loss of memory, visuospatial, language ... (Ver mais)

What Do We Know About Medical Cannabis in Neurological Disorders and What Are the Next Steps ?

OPEN ACCESS - Frontiers in Pharmacology - Revisão - 2022

Medical use of cannabis has been receiving growing attention over the last few decades in modern medicine.As we know that the endocannabinoid system i ... (Ver mais)

Methamphetamine and Cannabis: A Tale of Two Drugs and their Effects on HIV, Brain, and Behavior

OPEN ACCESS - The Journal of Neuroimmune Pharmacology - Revisão - 2020

HIV infection and drug use intersect epidemiologically, and their combination can result in complex effects on brain and behavior.The extent to w ... (Ver mais)

Medicinal Cannabis and Central Nervous System Disorders

OPEN ACCESS - Frontiers in Pharmacology - Revisão - 2022

Cannabinoids, including those found in cannabis, have shown promise as potential therapeutics for numerous health issues, including pathological pa ... (Ver mais)

Phytocannabinoids: General Aspects and Pharmacological Potential in Neurodegenerative Diseases

OPEN ACCESS - Current Neuropharmacology - Revisão - 2021

In the last few years research into Cannabis and its constituent phytocannabinoids has burgeoned, particularly in the potential application of novel ... (Ver mais)

Effects of Cannabis Use on the Protein and Lipid Profile of Olfactory Neuroepithelium Cells from Schizophrenia Patients Studied by Synchrotron - Based FTIR Spectroscopy

OPEN ACCESS - Biomolecules - Artigo Original - 2020

Schizophrenia (SCZ) is a neurodevelopmental disorder with a high genetic component, but the presence of environmental stressors can be important ... (Ver mais)

Cannabinoids for the Neuropsychiatric Symptoms of Dementia: A Systematic Review and Meta - Analysis

OPEN ACCESS - Canadian Psychiatric Association - Revisão - 2020

In 2016, the global number of individuals living with dementia was 43.8 million, representing a 117 % increase from 1990 — mainly due to incre ... (Ver mais)

Recent cannabis use in HIV is associated with reduced inflammatory markers in CSF and blood

OPEN ACCESS - Neurology Neuroimmunology & Neuroinflammation - Artigo Original - 2020

To determine whether cannabis may reduce HIV - related persistent inflammation, we evaluated the relationship of cannabis use in people with HIV (PWH ... (Ver mais)

A Review of the Potential Use of Pinene and Linalool as Terpene - Based Medicines for Brain Health: Discovering Novel Therapeutics in the Flavours and Fragrances of Cannabis

OPEN ACCESS - Frontiers in Psychiatry - Revisão - 2021

" Medicinal cannabis ” is defined as the use of cannabis - based products for the treatment of an illness.Investigations of cannabis compounds in psyc ... (Ver mais)

Cannabis and Canabidinoids on the Inflammatory Bowel Diseases: Going Beyond Misuse

OPEN ACCESS - International Journal of Molecular Sciences - Revisão - 2020

Inflammatory bowel diseases (IBD) are characterized by a chronic and recurrent gastrointestinal condition, including mainly ulcerative colitis (UC) ... (Ver mais)

Cannabis Use and Resting State Functional Connectivity in the Aging Brain

OPEN ACCESS - Frontiers in Aging Neuroscience - Revisão - 2022

Several lines of evidence suggest that older adults (aged 65 +) sharply increased their cannabis use over the last decade, highlighting a need to und ... (Ver mais)

Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer

OPEN ACCESS - BioMed Research International - Revisão - 2018

In the last decades, a lot of attention has been paid to the compounds present in medicinal Cannabis sativa L., such as Δ9 - tetrahydrocannabinol (Δ ... (Ver mais)

An Optimized Terpene Profile for a New Medical Cannabis Oil

OPEN ACCESS - Pharmaceutics. - Artigo Original - 2022

The purpose of this analytical study was to develop an advanced formulation of medical Cannabis oil (MCO) comparing the chemical profile of different ... (Ver mais)

Safety and tolerability of natural and synthetic cannabinoids in adults aged over 50 years: A systematic review and meta - analysis

OPEN ACCESS - PLoS Med - Revisão - 2021

Cannabinoid - based medicines (CBMs) are being used widely in the elderly.However, their safety and tolerability in older adults remains unclear.We ... (Ver mais)

How effective and safe is medical cannabis as a treatment of mental disorders ? A systematic review

OPEN ACCESS - European Archives of Psychiatry and Clinical Neuroscience - Revisão - 2019

We conducted a review of systematic reviews (SRs) and randomized - controlled trials (RCTs) to analyze efficacy and safety of cannabis - based medic ... (Ver mais)

A Systematic Review of the Neurocognitive Effects of Cannabis Use in Older Adults

OPEN ACCESS - Current Addiction Reports - Revisão - 2020

Older adults currently represent the fastest growing demographic of cannabis users, yet few studies have investigated the effects of cannabis use on co ... (Ver mais)

Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging

OPEN ACCESS - JAMA Neurology - Artigo Original - 2018

Synaptic loss is well established as the major structural correlate of cognitive impairment in Alzheimer disease (AD). The ability to measure synaptic ... (Ver mais)

Tetrahydrocannabinol-Rich Extracts From Cannabis Sativa L. Improve Glucose Consumption and Modulate Metabolic Complications Linked to Neurodegenerative Diseases in Isolated Rat Brains

OPEN ACCESS - Frontiers in Pharmacology - Artigo Original - 2020

Reduced brain glucose consumption arising from impaired glucose uptake and utilization has been linked to the pathogenesis and complications of neurode ... (Ver mais)

Immunomodulatory Role of CB2 Receptors in Emotional and Cognitive Disorders

OPEN ACCESS - Frontiers in Psychiatry - Artigo Original - 2022

Emotional behavior, memory, and learning have been associated with alterations in the immune system in neuropsychiatric and neurodegenerative diseases. ... (Ver mais)

Attenuation of Oxidative Stress by Cannabinoids and Cannabis Extracts in Differentiated Neuronal Cells

OPEN ACCESS - Pharmaceuticals (Basel). - Artigo Original - 2020

In this proof-of-concept study, the antioxidant activity of phytocannabinoids, namely cannabidiol (CBD) and Δ9- tetrahydrocannabinol (THC), were invest ... (Ver mais)

Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602

OPEN ACCESS - Biomolecules. - Artigo Original - 2020

The study documented here was aimed to find the molecular interactions of some of the cannabinoid constituents of cannabis with acetylcholinesterase (A ... (Ver mais)

Medication Development for Agitation and Aggression in Alzheimer Disease: Review and Discussion of Recent Randomized Clinical Trial Design

OPEN ACCESS - International Psychogeriatrics - Revisão - 2016

The management of disruptive neuropsychiatric symptom (NPS) such as agitation and aggression (A/A) is a major priority in caring for people with Alzhei ... (Ver mais)

Therapeutic Effects of Natural Drugs on Alzheimer’s Disease

OPEN ACCESS - Frontiers in Pharmacology - Revisão - 2019

Alzheimer disease (AD) is characterized as a chronic neurodegenerative disease associated with aging. The clinical manifestations of AD include latent ... (Ver mais)

Cannabinoids in the management of behavioral, psychological, and motor symptoms of neurocognitive disorders: a mixed studies systematic review

OPEN ACCESS - Journal of Cannabis Research - Revisão - 2022

We undertook this systematic review to determine the efficacy and safety of cannabis-based medicine as a treatment for behavioral, psychological, and m ... (Ver mais)

Safety, pharmacodynamics, and pharmacokinetics of multiple oral doses of delta-9-tetrahydrocannabinol in older persons with dementia

OPEN ACCESS - Psychopharmacology (Berl) - Artigo Original - 2015

Data on safety, pharmacodynamics, and pharmacokinetics of tetrahydrocannabinol (THC) are lacking in dementia patients.In this randomized, double-blind, ... (Ver mais)

Endocannabinoid Modulation in Neurodegenerative Diseases: In Pursuit of Certainty

OPEN ACCESS - Biology (Basel) - Revisão - 2022

eurodegenerative diseases are an increasing cause of global morbidity and mortality. They occur in the central nervous system (CNS) and lead to functio ... (Ver mais)

TRP Channels as Novel Targets for Endogenous Ligands: Focus on Endocannabinoids and Nociceptive Signalling

OPEN ACCESS - Current Neuropharmacology - Revisão - 2018

Chronic pain is a significant clinical problem and a very complex pathophysiological phenomenon. There is growing evidence that targeting the endocanna ... (Ver mais)

Filling the cannabis knowledge gap

OPEN ACCESS - Canadian Medical Association Journal - Relato de Caso - 2015

Now educational opportunities are emerging. The College of Family Physicians of Canada (CFPC) has approved seven programs on dried cannabis; the two ... (Ver mais)

Cannabinoid Hyperemesis Syndrome: A Case Report of an Underdiagnosed Condition

OPEN ACCESS - Portuguese Journal of Gastroenterology - Relato de Caso - 2021

Cannabinoid hyperemesis syndrome (CHS) is characterized by episodic bursts of nausea, vomiting and abdominal pain, affecting chronic cannabis users. ... (Ver mais)

Druggable Targets in Endocannabinoid Signaling

OPEN ACCESS - Advances in Experimental Medicine and Biology - Revisão - 2020

Cannabis and cannabinoid-based extracts have long been utilized for their perceived therapeutic value, and support for the legalization of cannabis f ... (Ver mais)

Novel role of cannabinoid receptor 2 in inhibiting EGF/EGFR and IGF-I/IGF-IR pathways in breast cancer

OPEN ACCESS - Oncotarget. - Artigo Original - 2017

Breast cancer is the second leading cause of cancer deaths among women. Cannabinoid receptor 2 (CNR2 or CB2) is an integral part of the endocannabino ... (Ver mais)

The Endocannabinoid Signaling System in the CNS: A Primer

OPEN ACCESS - International Review of Neurobiology - Artigo Original - 2019

The purpose of this chapter is to provide an introduction to the mechanisms for the regulation of endocannabinoid signaling through CB1 cannabinoid r ... (Ver mais)

Exploration of Multiverse Activities of Endocannabinoids in Biological Systems

OPEN ACCESS - International Journal of Molecular Sciences -